Abstract
BackgroundIn individuals with cystic fibrosis (CF), colonization with methicillin-resistant Staphylococcus aureus (MRSA) was reported to be associated with a deterioration of pulmonary disease as reflected by an accelerated decline in lung function. Thus, an early eradication of MRSA could be beneficial in these patients. Here, we report on an intensified MRSA eradication protocol.MethodsSince 2012 a protocol for the eradication of newly acquired MRSA has been used in our CF Clinic, combining oral rifampicin and fusidic acid, inhaled vancomycin, nasal mupirocin, local antiseptic treatment and hygienic directives all of which are applied for only 7 days during an inpatient hospital stay.ResultsSince 2012 seven patients (3 male, 4 female; age range 4 to 30 years) newly acquired MRSA. In 6 of the 7 patients (86%) successful eradication of MRSA was achieved upon first treatment using the protocol described above. In one patient a second course of treatment was performed which, however, also failed to eliminate the colonizing MRSA.ConclusionsOur protocol led to an eradication rate of 86%. The impact of each individual component of the protocol remains to be determined.
Highlights
In individuals with cystic fibrosis (CF), colonization with methicillin-resistant Staphylococcus aureus (MRSA) was reported to be associated with a deterioration of pulmonary disease as reflected by an accelerated decline in lung function
The chronic colonization with MRSA seems to be associated with a worsening of the pulmonary disease, with an accelerated decline in lung function and/or a prolonged recovery period after clinical exacerbations [1,2,3, 6, 7]
Several protocols for an early eradication of MRSA have been reported to prevent negative consequences that might result from chronic MRSA colonization [1, 2, 8]
Summary
In individuals with cystic fibrosis (CF), colonization with methicillin-resistant Staphylococcus aureus (MRSA) was reported to be associated with a deterioration of pulmonary disease as reflected by an accelerated decline in lung function. The prevalence of methicillin-resistant Staphylococcus aureus (MRSA) colonization in patients with cystic fibrosis (CF) has increased over the past years. The chronic colonization with MRSA seems to be associated with a worsening of the pulmonary disease, with an accelerated decline in lung function and/or a prolonged recovery period after clinical exacerbations [1,2,3, 6, 7]. Several protocols for an early eradication of MRSA have been reported to prevent negative consequences that might result from chronic MRSA colonization [1, 2, 8].
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