Abstract
RECURRING RETINAL hemorrhage in young persons is frequently associated with ophthalmoscopically recognizable periphlebitis. In most cases the patient gives a cutaneous reaction to tuberculin, and in the cases in which the retina has been examined microscopically nodular foci of epithelial cells have been observed along the veins. These facts constitute strong evidence that the condition termed by Igersheimer adolescentium is an entity, that it is caused by tuberculosis and that to it most cases of so-called Eales's disease belong. It is uncertain whether the periphlebitis is directly hematogenous or results from dissemination of the infection by way of the vitreous. Microscopically, I have seen such foci along retinal veins in the vicinity of localized active foci of tuberculous chorioretinitis, and there they were obviously due to migration of infected macrophages within the vitreous. The hemorrhages evidently result from engorgement of capillaries and small veins. When this engorgement is severe
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