Successful delivery after the transfer of embryos obtained from a cohort of incompletely in vivo matured oocytes at retrieval time

Abstract

To report a case of successful delivery of a healthy baby after intracytoplasmic sperm injection (ICSI) in a patient with no mature oocytes at the time of oocyte retrieval. Case report. Department of Reproductive Medicine. After a controlled ovarian hyperstimulation cycle, a total of seven immature oocytes were collected. Medical management. The timing of polar body extrusion was checked every 2 hours, and ICSI was performed as soon as the first polar body was extruded. Following incubation in culture medium, five oocytes reached the metaphase II stage within 8-8.5 hours. Three oocytes were fertilized after ICSI, and two of three cleaved embryos were transferred on day 3. The embryo transfer was followed by a single pregnancy and the delivery of a healthy baby. This case report demonstrates that embryos obtained from in vitro matured oocytes retain the developmental competence for full-term. It illustrates the importance of regularly monitoring the polar body extrusion when all collected oocytes are immature.