Abstract
Objective: Measurements of the systematic variation of backscattered ultrasonic energy from myocardium over the heart cycle (cyclic variation, CV) have been successfully employed to characterize a wide spectrum of cardiac pathologies in large animal models and human subjects. The purpose of this study was to evaluate the feasibility of extending CV measurements to the study of genetically manipulated mouse models of cardiac diseases as a method for developing further insights into the disease-altered properties of the myocardium and its characterization with ultrasound.
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