Successful combination treatment of metastatic ductal carcinoma of the pancreas tail pT4N0M1(per). Clinical case

Abstract

Pancreatic tail cancer has a poor prognosis and may be unresectable at the time of diagnosis, since it is asymptomatic and often has invasion into adjacent organs, and also has a high metastatic potential, where the target organs are the liver, lungs, bones, as well as the parietal and visceral peritoneum, adrenal glands. Radical resection of the pancreas in such cases is impractical. The gold standard of treatment is systemic chemotherapy. We describe the successful resection of locally advanced pancreatic tail cancer with metastases along the peritoneum of the large omentum after 14 courses of chemotherapy according to the mFOLFIRINOX (oxaliplatin 85 mg/m2 intravenously for 120 min, irinotecan 150 mg/m2 intravenously for 90 min, leucovorin 400 mg/m2 intravenously for 120 min, 5-fluorouracil 2400 mg/m2 intravenous infusion for 46 hours, cycle 14 days).