Abstract
In recent years, the translation of genomic discoveries into mainstream medical practice and public health has gained momentum, facilitated by the advent of new technologies. However, there are often major discrepancies in the pace of implementation of genomic medicine between developed and developing/resource-limited countries. The main reason does not only lie in the limitation of resources but also in the slow pace of adoption of the new findings and the poor understanding of the potential that this new discipline offers to rationalize medical diagnosis and treatment. Here, we present and critically discuss examples from the successful implementation of genomic medicine in resource-limited countries, focusing on pharmacogenomics, genome informatics, and public health genomics, emphasizing in the latter case genomic education, stakeholder analysis, and economics in pharmacogenomics. These examples can be considered as model cases and be readily replicated for the wide implementation of pharmacogenomics and genomic medicine in other resource-limited environments.
Highlights
Advances in genomics and related technologies have revolutionized the practice of medicine by means of better diagnosing and/or prognosing human inherited disorders and cancer and rationalizing drug use [1]
Translation of genomic findings into health care and health systems has been catalyzed by the advent of genome-wide studies, in which next-generation sequencing for either targeted, whole-exome, and/or wholegenome sequence analyses stands as the most powerful approach [2]
Translating genomics into health care of resource-limited countries Successful translation of genomics into genomic medicine relies on several related disciplines, such as population genomics, pharmacogenomics, or informatics and the approach/task of public health genomics, which are frequently intersected
Summary
Advances in genomics and related technologies have revolutionized the practice of medicine by means of better diagnosing and/or prognosing human inherited disorders and cancer and rationalizing drug use [1]. Translating genomics into health care of resource-limited countries Successful translation of genomics into genomic medicine relies on several related disciplines, such as population genomics, pharmacogenomics, or informatics and the approach/task of public health genomics, which are frequently intersected.
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