Abstract
Although integrins are known to be mechano-sensitive and to possess many subtypes that have distinct physiological roles, subtype-specific mechano-sensing is yet to be characterized. We show that integrin α4β1 and RGD-binding integrins, primarily αVβ1, need to experience markedly different tension for stable cell spreading. Furthermore, actin assembled downstream of α4β1 forms cross-linked networks in circularly spread cells, is in rapid retrograde flow, and exerts low forces from actin polymerization.
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