Abstract
Introduction: Abundant stroma of pancreatic ductal adenocarcinoma (PDAC) produces various microenvironmental < niche> factors. PDAC organoids have different dependencies on niche factors; while there are PDAC subtypes independent of niche factors as represented by conventional pancreatic cancer cell lines, there are also PDAC subtypes that strongly depend on niche factors. We performed the PDAC subtype classification based on niche dependency and their morphological phenotypes and investigated the correlation between niche dependency and drug treatment response.
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