Subtly Altered Topological Asymmetry of Brain Structural Covariance Networks in Autism Spectrum Disorder Across 43 Datasets From the Enigma Consortium

Abstract

Small average differences in the left-right asymmetry of cerebral cortical thickness have been reported in individuals with autism spectrum disorder (ASD) compared to typically developing controls, affecting widespread cortical regions. The possible impacts of these regional alterations in terms of structural network effects have not previously been characterized. Inter-regional morphological covariance analysis can capture coordinated maturational-trophic networks between different cortical areas at macroscale.