Subtleties in asymmetric catalyst structure: the resolution of a 6-phospha-2,4,8-trioxa-adamantane and its applications in asymmetric hydrogenation catalysis

Abstract

An efficient, classical resolution of the versatile P-ligand intermediate 6-phospha-2,4,8-trioxa-adamantane (CgPH) is described and the rhodium complex of the optically pure secondary phosphine beta-CgPH is an active and moderately selective asymmetric hydrogenation catalyst.