Subtle visual change in a virtual environment induces heterogeneous remapping systematically in CA1, but not CA3

Abstract

Environmental change may lead to new memories or modify old ones, but the underlying neural mechanisms are largely unclear. We recorded hippocampal place cells simultaneously from CA1 and CA3 in a virtual reality environment. Compared with CA1, place cells in CA3 are more tolerant of individual landmark changes but undergo orthogonal changes to code distinctively different environments. As visual noise (virtual fog) is introduced to a visually enriched environment, place cells in CA1 split into two subpopulations: in one, place cells maintain their field locations while changing their firing rates to reflect sensory changes; in the other, place cells exhibit global remapping in response to the contextual change. In contrast, place cells in CA3 exhibit mainly rate remapping under the same conditions. Our results suggest that CA1 may simultaneously represent heterogeneous maps of the same environment when subtle visual noise induces both sensory and contextual changes.