Abstract
Subthreshold resonance has been observed in many excitatory/inhibitory neurons in the brain. It is suggested that such resonance phenomenon plays an important role in behavioral or perceptual functions in animals. However its mechanism and role remains unknown. Subthreshold resonance oscillation observed in a neuron suggests that a neuron has the frequency selectivity for various external inputs given to the brain. By advances in physiological experimental techniques, various voltage-dependent channels are thought to be involved in the generation of these resonance oscillations. Among these channels, a persistent sodium channel and a hyperpolarization-activated cation channel are said to mediate the generation of the subthreshold resonance oscillation observed in entorhinal cortex neurons and hippocampal pyramidal neurons. In this proposal, we examine how the external inputs influence the generation of action potentials at the neuron model with a persistent sodium channel and a hyperpolarization-activated cation channel parameters by using computer simulations. Furthermore, the role of DC bias current input in the neuron model is also discussed.
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