Abstract
Objective To assess the specific effect and side effect of high-frequency deep brain stimulation of subthalamic nucleus(STN-DBS) in controlling the tremor, rigidity and bradykinesia of Parkinson's disease (PD), and to investigate the best portion of STN for electrode lead implanted.Methods Twenty-six patients with PD were selected for STN-DBS. Surgery was performed under local anesthesia using Leksell model G frame. Implants were placed into STN using MRI-based stereotaxy, microelectrode recording, and intraoperative test stimulation. The coordinate of STN: X=11mm～13mm, Y=-1mm～-3mm, Z=-7mm. The effect was evaluated by the neurologist, three patients had implanted permanent lead for chronic stimulation.Results Intraoperative STN test stimulation strongly improved most of the parkinsonian symptoms and indicated that the dorsal-lateral part of STN was best position for placement of lead. It induced dysphasia if the lead was over deep and too lateral. Conclusions STN-DBS is effective for controlling cardinal symptoms of PD, the dorsal-lateral part of STN is best place for lead.
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