Subthalamic nucleus D5 receptors: role in the pathophysiology and therapy of Parkinson's disease

Abstract

Event Abstract Back to Event Subthalamic nucleus D5 receptors: role in the pathophysiology and therapy of Parkinson's disease Jonathan Chetrit1* 1 Université de Bordeaux 2, Laboratoire MAC, France Burst firing in basal ganglia is a hallmark of Parkinson’s disease (PD). Activation of dopamine D5 receptors (DRD5), which are characterized by a high constitutive activity, has been shown to potentiate burst firing of subthalamic nucleus (STN) neurons in vitro. The aim of the present study was to investigate whether inhibiting the constitutive activity of DRD5 results in depressed burst firing of STN neurons and consequently improves motor disturbances in a rat model of PD. First, we confirmed that DRD5 exhibits a high constitutive activity in vivo, leading to GTP γS experiments on brain slices containing STN. Using α-flupentixol as a DRD5 invert-agonist we have studied the effect of constitutive activity blockade on locomotor activity and on in vivo extracellularly recorded STN neuronal activity in an experimental modele of PD: 6-hydroxydopamine (6-OHDA)-lesioned rats. Local injection of α-flupentixol directly into the STN improved locomotor activity of 6-OHDA-lesioned rats and diminished bursty neurons proportion. Taking together, our results demonstrate that DRD5 located in the STN are involved in the pathophysiology of PD and that local administration of invert-agonist of these receptors could be beneficial in the treatment of PD. Conference: 3rd Mediterranean Conference of Neuroscience , Alexandria, Egypt, 13 Dec - 16 Dec, 2009. Presentation Type: Oral Presentation Topic: Symposium 26 - Exploring new therapies for Parkinson's disease" Citation: Chetrit J (2009). Subthalamic nucleus D5 receptors: role in the pathophysiology and therapy of Parkinson's disease. Front. Neurosci. Conference Abstract: 3rd Mediterranean Conference of Neuroscience . doi: 10.3389/conf.neuro.01.2009.16.139 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 24 Nov 2009; Published Online: 24 Nov 2009. * Correspondence: Jonathan Chetrit, Université de Bordeaux 2, Laboratoire MAC, Bordeaux, France, jonathanchetrit@yahoo.fr Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Jonathan Chetrit Google Jonathan Chetrit Google Scholar Jonathan Chetrit PubMed Jonathan Chetrit Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.