Abstract

© 2014 Wiley-VCH Verlag & Co. KGaA. All rights reserved. In comparison, both mid-infrared (MIR) and Raman spectroscopic studies offer a substantially higher degree of chemical specificity, but their use in their traditional form has been so far confined to only shallow layers in turbid media. A substantial extension to the penetration depth of Raman spectroscopy was accomplished utilizing the properties of diffuse light in analogy with near-infrared (NIR) absorption tomography or fluorescence spectroscopy. This chapter reviews recent developments in this area and illustrates the utility of these methods on several practical examples. The advent of new noninvasive Raman spectroscopic techniques promises to have a significant impact on many biomedical, security, and industrial analytical applications. Schulmerich et al. have demonstrated that spatially offset Raman spectroscopy (SORS) concept can be used as a tomographic tool capable of forming chemically specific images of subsurface structures.

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