Substrates of kinin-releasing enzymes isolated from horse plasma.

Abstract

KININOGEN has been isolated from horse plasma1, bovine plasma2–4, human plasma5 and rabbit plasma6. Several authors, however, have shown that plasma contains at least two kininogens with affinities for different releasing enzymes7–10. Recently, Jacobsen11 detected the presence of two kininogens in human, dog and rabbit plasma—one which forms kinin with plasma kallikrein and another which forms kinin only when incubated with glandular kallikrein.