Substrate stimulation of renal tubular secretion of penicillin and diodone in dogs

Abstract

Chronic experiments on dogs showed that repeated (three times a day for 3 days) intramuscular injection of 40 mg/kg penicillin or 100 mg/kg diodone leads to an increase in the maximal rate of secretion of these substances in the kidneys. The results are regarded as direct proof of the existence of substrate stimulation of tubular secretion of organic substances.