Abstract
We provide here a simplified mechanochemical model to describe the role of substrate stiffness in mediating the chemical reactions between integrins on cell membrane and ligands immobilized on the substrate. By taking into account the energy input for integrin activation on a compliant substrate, Our simulation shows that integrin activation and the downstream integrin clustering can be regulated by substrate stiffness in a value-dependent manner, which is consistent with previous experimental studies.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
