Substrate specificity of the CYC2 enzyme from Kitasatospora griseola: production of sclarene, biformene, and novel bicyclic diterpenes by the enzymatic reactions of labdane- and halimane-type diterpene diphosphates

Chiaki Nakano,Tsutomu Hoshino,Tsutomu Sato,Tomonobu Toyomasu,Tohru Dairi,Takeshi Sassa

doi:10.1016/j.tetlet.2009.10.110

Substrate specificity of the CYC2 enzyme from Kitasatospora griseola: production of sclarene, biformene, and novel bicyclic diterpenes by the enzymatic reactions of labdane- and halimane-type diterpene diphosphates

Chiaki Nakano, Tsutomu Hoshino + Show 4 more

https://doi.org/10.1016/j.tetlet.2009.10.110

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Journal: Tetrahedron Letters	Publication Date: Oct 27, 2009
Citations: 14

Affiliation: Niigata University, Yamagata University, Toyama Prefectural University

#Bicyclic Diterpenes #Copalyl Diphosphate + Show 5 more

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Abstract

The enzymatic reaction of copalyl diphosphate (CDP), ent-CDP, syn-CDP, and tuberculosinyl diphosphate with the CYC2 enzyme from Kitasatospora griseola afforded sclarene, biformene, and novel diterpenes having a buta-1,3-diene moiety in the side chain. The substrate specificity of the CYC2 is discussed.

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