Abstract
The substrate specificity of transport was studied in mouse brain slices by measuring the inhibition of uptake of individual amino acids by related compounds, and was found to be similar in many ways to that of other systems. More than one amino acid transport site was found to exist, but not a specific one for each amino acid. At least six transport sites could be differentiated, each one utilized by a group of amino acids of similar charge and structure as their primary site of entry. These groups, or classes, are: (1) small neutral, (2) large neutral, (3) small basic, (4) large basic, (5) acidic, and (6) GABA. A particular amino acid seems to have an affinity to more than one transport site, a high affinity to its primary site of transport, and a lower affinity to a secondary site of entry.
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