Abstract
AbstractA novel system for substrate‐specific activation of carboxylic acids leading to the formation of carboxamides has been developed in our laboratory. A combination of a water‐soluble dehydrocondensing agent, 4‐(4,6‐dimethoxy‐1,3,5‐triazin‐2‐yl)‐4‐methylmorpholinium chloride (DMT‐MM), and an inverse phase‐transfer catalyst (IPTC) (hydroxypropyl)cyclodextrin (HP‐β‐CD), in a water/ether biphasic solvent system was found to be most effective. A lipophilic carboxylic acid with a strong affinity for the cavity of HP‐β‐CD can be selectively transferred to the aqueous phase and predominantly reacts with DMT‐MM, dissolving in the aqueous phase. The substrate specificity was similar to that observed with a complex artificial enzyme based on CD. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004)
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
