Year-end Sale % OFF 
Abstract
Recurrence and metastasis rank among the most prominent clinical problems in colorectal cancer (CRC) treatment. Colorectal tumorigenic cell was identified to explore the process of CRC stemness maintenance and progression by simulating tumor mechanical properties. Here, we show that F-actin regulator KIAA1211 negatively correlates with CRC progression, stemness, and metastasis. Mechanistically, decreased KIAA1211 in soft substrates induces YAP retention in the cytoplasm, restores the repression effect on stemness markers NANOG and OCT4, thereby promotes CRC stemness and metastasis. Furthermore, KIAA1211 deficiency promotes colorectal tumor cell softening and regulates EMT states, contributing to its metastasis potential. Clinically, KIAA1211 expression is correlated with malignant degrees and metastasis in CRC patients. To sum up, our work uncovers an essential role of actin regulator KIAA1211 in anti-cancer and mechanical signal transduction of extracellular matrix in CRC.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
