Abstract
Substrate-controlled divergent reactions of between salicylaldehydes and acrylates have been developed. By using methyl acrylate as the substrate with salicylaldehydes, a domino reaction was established, delivering coumarins with good yield (up to 81% yields) and high chemoselectivity under mild conditions. Whereas the methyl acrylate was changed to tert-butyl acrylate or iso-propyl acrylate, the classical Morita − Baylis − Hillman adducts were produced in good yields (up to 75% yields) under near exclusivity under the otherwise identical reaction conditions, without any other competitive products. Additionally, the synthetic utility of the present methodology was further demonstrated by synthetic transformation. The structure of the typical product was unambiguously established by single crystal X-ray diffraction analysis.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
