Abstract
ABSTRACT The mechanisms of substitution in transition metal complexes are reviewed with particular emphasis on recent developments. Strong support is available for a dissociative mechanism in formation reactions, in which the release of water from the metal ion controls the rate of entry of ligand. This generalization breaks down in the case of certain protonated ligands as well as multidentate ligands of special structure. Some substitution reactions of carbonic anhydrase (in the native and cobalt forms) are reviewed. These include the interaction of enzyme with inhibitors, including sulphonamides and cyanate ion. Kinetic data for these are discussed. The results of studies of the regeneration of the haloenzyme from apoenzyme and metal ion or metal complexes are given and discussed.
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