Abstract
Department of Obstetrics and Gynaecology, Tzanion General Hospital, Piraeus, Greece In the rat, bilateral ovariectomy performed during the first 4 days of pregnancy results in inhibition of implantation, while spaying after mid-gestation induces abortion or resorption of the fetuses (Haterius, 1936; Courrier & Cologne, 1950). Daily injections of progesterone have been reported to maintain pregnancy in ovariectomized rats (Stucki, 1958; Talwalker, Krahenbuhl, & Desaulles, 1966), but it is possible that oestrogen is also necessary, as suggested by Nutting & Meyer (1964) and Dickmann & Hart (1972). The present study was designed not only to re-examine the above findings, but also to investigate the role of the ovary throughout pregnancy using the technique of egg transfer. Ovariectomized female rats were made pseudopregnant by injections of oestrogen and/or progesterone and then pregnant by egg transplantation. High rates of pregnancies continuing to term were interpreted as an indication of the proper treatment. Mature
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