Year-end Sale % OFF 
Abstract
This work has been carried out to explore the reaction of 2-cyanoacetohydrazide with cyclohexanone to form 4,5,6,7-tetrahydroindole derivatives. 2-Hydroxy-4,5,6,7-tetrahydro-1H-indole-3-carbonitrile was used as the starting material for a series of novel heterocyclic products containing fused oxazine, pyran, pyrazole, pyridazine, and thiophene rings. The antitumor activity evaluation of the newly synthesized compounds against three human tumor cells lines, breast adenocarcinoma (MCF-7), non-small cell lung cancer (NCI-H460), and CNS cancer (SF-268), and with normal fibroblast cells (WI 38) showed that some of these compounds exhibit much higher inhibitory effects towards the three tumor cell lines than the reference drug doxorubicin while being minimally active towards normal cells.
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
