Abstract
The dependence of electronic absorption spectra antimicrobial property on the substituent position was investigated using three Schiff bases derived from salicylaldehyde and isomeric aminobenzoic acids in three solvents of different polarities. The absorption maxima in all three solvents exhibited dependence on the position of substituent with the absorption maxima undergoing a red shift as solvent polarity increased. The in vitro antibacterial activity of the compounds against some clinically important bacteria namely Escherichia coli (ATCC 25922), Pseudomonas aeruginosa (ATCC 27853), Staphylococcus aureus (ATCC 25923), Enterococcus feacalis (ATCC 29212) was determined in N,N”-dimethylformamide and 1,4-dioxane using the agar dilution method. The results revealed that the ortho and meta substituted Schiff bases exhibited better antimicrobial activity in the non-polar solvent.
Highlights
Schiff base compounds have been shown to be promising leads for the design of efficient antimicrobial agents as a result of the broad range of biological activities exhibited by these compounds
The dependence of electronic absorption spectra antimicrobial property on the substituent position was investigated using three Schiff bases derived from salicylaldehyde and isomeric aminobenzoic acids in three solvents of different polarities
The results revealed that the ortho and meta substituted Schiff bases exhibited better antimicrobial activity in the non-polar solvent
Summary
Schiff base compounds have been shown to be promising leads for the design of efficient antimicrobial agents as a result of the broad range of biological activities exhibited by these compounds. These compounds and their metal complexes are reported to exhibit antifungal, antibacterial, antimalarial, antiproliferative, anti-inflammatory, antiviral and antipyretic properties [1,2,3]. Schiff bases composed of salicyaldehydes are very promising in the search of new functional materials They exhibit a variety of biological activities [5,6] as well as show important photochromism where light absorption causes interconversion between enolimine and keto-amine tautomers through intramolecular hydrogen transfer
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