Substantiation of the composition of a rectal dosage form containing ketoprofen and glucosamine sulfate for the treatment of rheumatoid arthritis

Abstract

In the course of this study, it was found that currently more than 30 million people are forced to take non-steroidal anti-inflammatory drugs (NSAIDs) daily. It is reliably known that nonsteroidal anti-inflammatory drugs with prolonged use cause a number of side effects, the main of which are erosive and ulcerative changes in the mucous membrane of the gastrointestinal tract. Special attention is paid to the classification and comparative evaluation of various NSAIDs and possible complications in the case of their use. As a result of the performed analysis, it was found that rectal forms have been developed for most NSAIDs, which is convenient for use in pediatric practice, in patients with gastropathies, nausea, vomiting, swallowing disorders, in an unconscious state. The common sides of their pharmacological action are anti-inflammatory, antipyretic, analgesic effects due to inhibition of cyclooxygenase I, II activity and leading to disruption of arachidonic acid metabolism with suppression of prostaglandin synthesis in the focus of inflammation. Data analysis showed that NSAID suppositories are prescribed for: articular syndrome; pain in the spine, neuralgia, myalgia, traumatic inflammation of soft tissues and musculoskeletal system; rheumatism, diffuse connective tissue diseases; dysmenorrhea.