Abstract
Introduction. The low quality of environmental and educational factors negatively impact on children’s health in primary school. Data and methods. The objects of the study were indices of the content of chemicals in the atmospheric air and classrooms, drinking water; indices of the intensity of the educational process, biochemical indices of negative effects in children aged of 7-10 years, exposed to the combined effects of factors of the educational environment and hygienic conditions at the initial stage of education with various types of training programs. Results. An unsatisfactory quality of atmospheric air in the territories of educational institutions and classrooms was found for the content of phenol and formaldehyde, the constant presence of nickel and chromium. Phenol in the blood was substantiated as a marker of inhalation exposure and index marker of educational load factors - the use of technical teaching means in the educational process, intellectual and emotional loads, the monotony of loads. The connection with the combined effect of dissimilar factors has been established for classes of comorbid diseases of the nervous system and digestive organs. Two indices have been substantiated as biomarkers of the comorbidity in schoolchildren under the combined effect of dissimilar factors: acetylcholinesterase and pepsinogen I in blood serum. Discussion. The work established sequential continuous logical chain of links ‘the combined effect of environment, the educational factors - a change in indices of negative impact’. So far, the shown likelihood of comorbid diseases of the nervous system and digestive organs makes it possible to predict an increase in the overall incidence of diseases in junior schoolchildren under aerogenic exposure and educational load (the level of additional cases is about 300 per year). Conclusion. The chemical environmental and educational factors and biomarkers of comorbidity should be taken into account when developing measures aimed at minimizing the risks of the gain in the comorbidity involving the nervous system and digestive organs under the combined impact of dissimilar factors.
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