Substantiation of a noninvasive method of administration of drugs at the prelymphatic level

Abstract

UDC 615.47.032.076.9 Parenteral administration (intramuscular, subcutaneous, or intravenous injection) of drugs is widely used in clinical practice. However, this method of drug administration does not meet the requirements of modern medicine because of low productivity, problems with sterilization of syringes and needles, and the hazard of transmission of such infections as virus hepatitis, AIDS, etc. Use of jet injectors [4] is a significant improvement on this method. A high-speed jet destroys structure of biological tissues at the site of injection and saturates it with drug. This exerts a strong effect on the topographic features of the site of injection: skin, hypodermic fatty tissue, fascia of muscles, muscles, muscular fascial spaces, blood and lymphatic vessels, and capillary bed. This is especially dangerous if the site of injection lies near the focus of an inflammatory or pyo-necrotic process because of the hazard of dissemination of the infection. Besides, jet injection injures blood and lymph microcapillary bed, thereby interfering with the processes of drainage, detoxication, metabolism, and regeneration in the infection focus. The lymphatic system is one of the main functional systems of human body [3, 5]. It provides various mechanisms of intoxication: mechanical (filtration), biochemical (catabolism of toxins), biological (immune reactions, phagocytosis). Therapy of the lymphatic system should support its function of detoxication.