Substance P/NK1R Antagonistic Effect of 17-Trifluoromethyl Phenyl Trinor Prostaglandin F2α in Breast Cancer

Abstract

17-Trifluoromethyl phenyl trinor prostaglandin F2α (17-TPGF2α) is extracted from a Zinc database, but its value for inhibiting breast cancer (BC) through the substance P (SP)/NK1R system remains unknown. This study was designed to investigate the potential antagonist effect of 17-TPGF2α through neurokinin 1 receptor (NK1R). The effect of 17-TPGF2α on the proliferation and apoptosis of BC cell lines was determined through in vitro cell lines. Based on in vitro results we planned to investigate anticancer activity in female Balb/c and used subcutaneous (SC) injection of DMBA for cancer induction. Oral administration of 17-TPGF2α significantly suppresses the tumor volume as compared with an untreated group. The serum parameters like ALP, AST, and ALT and hematological parameters were normalized in test treated group. Histological examination revealed normal histoarchitecture of the mammary gland and focal areas showed minimal inflammatory cell infiltration. There is no necrosis is seen in both test treated and standard treated groups when compared with the DMBA group. All these findings concluded that 17-TPGF2α may have potential as a novel antitumor candidate for BC.