Abstract
The substance P (SP) antagonists ( d-Pro 4, d-Trp 7,9, Leu 11) SP(4–11), ( d-Pro 4, d-Trp 7,9, Phe 11)SP(4–11) and ( d-Pro 4, d-Trp[ 7,9,10, Leu 11) SP(4–11) were infused into the lateral ventricles (i.c.v.) and their effects on spontaneous and drug-induced locomotor activity were investigated. The drug DiMeC7, the stable substance P agonist, was used to stimulate locomotor activity because of its prolonged action. Only ( d-Pro 4, d-Trp 7,9,10) SP (4–11) was found to attenuate the drug-induced increases in motor activity, indicating that it is a substance P antagonist with activity in the CNS.
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