Abstract
ObjectiveThere is a limited information about the role of Substance P (SP) in acute pain nociception following surgical stimulation in patients with a chronic inflammatory state not to mention the link between this neuropeptide level changes and intensity of pain. The goal of the research was to find the correlation between SP level changes and acute pain intensity in patients with rheumatoid arthritis undergoing elective orthopedic surgery.Material and MethodsPatients with rheumatoid arthritis (RA) were enrolled in the study. The correlation between acute pain intensity and concentration of SP in serum as well as in drainage fluid from postoperative wound was assessed in patients with RA who underwent Total Knee Replacement (TKA) under spinal anesthesia.ResultsIn patients with RA a correlation between intensity of acute pain and serum SP was found postoperatively, whereas there was no correlation between intensity of acute pain and concentration of SP in drainage fluid.Conclusions1. The correlation between acute pain intensity and SP serum concentration was found postoperatively in patients with RA. 2. The correlation between acute pain intensity and SP concentration in drainage fluid was not found postoperatively in patients with RA.
Highlights
A great deal of recent evidence suggests that substance P (SP) and its receptors are involved in joint inflammation and associated with some aspects of the pathophysiology of rheumatoid arthritis (RA) [1], [2].PLOS ONE | DOI:10.1371/journal.pone.0146400 January 5, 2016Substance P and Acute PainTotal Knee Arthroplasty (TKA) is a useful surgical procedure for pain relief, which much improves the patient’s life comfort.The acute postoperative pain is the direct consequence of the knee surgery following nociceptors excitation inside injured tissue.There is a limited information describing the role of SP during acute nociception following surgical stimulation in patients with a chronic inflammatory state
The correlation between acute pain intensity and concentration of SP in serum as well as in drainage fluid from postoperative wound was assessed in patients with RA who underwent Total Knee Replacement (TKA) under spinal anesthesia
In patients with RA a correlation between intensity of acute pain and serum SP was found postoperatively, whereas there was no correlation between intensity of acute pain and concentration of SP in drainage fluid
Summary
There is a limited information about the role of Substance P (SP) in acute pain nociception following surgical stimulation in patients with a chronic inflammatory state not to mention the link between this neuropeptide level changes and intensity of pain.
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