Abstract
Microinjection of a substance P analogue (1 mM; 7 or 10 nl) into laminae I and II of the L 7 dorsal horn of decerebrate cats significantly potentiated ( P<0.05) the increase in arterial pressure evoked by microinjection of l-glutamate (109 mM; 7 or 10 nl) into these spinal sites. Microinjection of the substance P analogues (i.e., GR73638 and [Sar 9,Met(O 2) 11]-substance P) which were selective NK-1 receptor agonists, had no impact on the cardioacceleration evoked by microinjection of l-glutamate ( P>0.05). In addition, microinjection of these analogues had no effect on the modest and non-significant increase in phrenic nerve discharge evoked by l-glutamate. We conclude that stimulation of NK-1 receptors in the superficial laminae of the dorsal horn potentiates the pressor responses to microinjection of l-glutamate.
Published Version
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