Abstract
Immunohistochemistry has been used to investigate disulphide linked and non-disulphide linked forms of the T cell receptor γ/δ heterodimer (TCR γ/δ) in blood and epithelium of normal human small intestine, intestine of patients with untreated coeliac disease (in whom T cells expressing TCR γ/δ are disproportionately raised) and intestine of patients with tropical malabsorption. In blood from adult volunteers, 90% of T cells using TCR γ/δ use the disulphide linked form. In contrast, in the epithelium in normal small intestine, coeliac disease and tropical malabsorption, most of the T cells expressing TCR γ/δ use the non-disulphide linked form. This is especially prominent in untreated coeliac disease where the increase in TCR γ/δ T cells is mainly restricted to those using the non-disulphide linked form.
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