Abstract
Well defined ring-shaped and rectangular particles are described as intracellular components of post-ribosomal cytosol of HeLa cells. Their morphology might be identical with particles recently isolated from plasma cell tumors and independently from the culture medium of malignant cells. The HeLa particles exist throughout post-ribosomal extracts from 30-10S; however, the highest concentration and best resolution exists at approx. 14–17S. Ultrastructure by electron microscopy indicates aggregation of the particles at higher sedimentation values. The possible relationship of high molecular weight forms of protein synthesis translational enzymes with both the intra- and extracellular particles has been explored.
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