Abstract
Purpose: Anterior cruciate ligament (ACL) rupture is associated with acute joint trauma and chronically altered joint mechanics, and with increased risk of incident radiographic knee OA. Using quantitative MRI, we have shown that the mean femorotibial cartilage thickness increases significantly in young adults after ACL rupture, and that this increase had a similar rate during the first 2 years (BL→Y2) and the subsequent 3 years (Y2→Y5). The purpose of the present study was to compare cartilage thickness change in femorotibial subregions during early (BL→Y2) and later (Y2→Y5) followup, using location-independent analysis and novel disease activity (i.e. subregional cartilage thickness change summary) scores.
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