Abstract

The distribution of T lymphocytes that bear Fc receptors for IgG and IgM (T G and T M) has been investigated in 22 patients with primary biliary cirrhosis. Absolute numbers and percentages of T lymphocytes and of T G and T M lymphocytes were decreased, while percentages and absolute numbers of lymphocytes without a detectable Fc receptor for IgG and IgM (T nonG-nonM) were markedly increased. These results are not completely explained by the masking of the Fc receptor by immune complexes since enzymatic treatment of lymphocytes corrected these alterations only partially. These data suggest a faulty regulation of immunocompetent cells in patients with primary biliary cirrhosis.

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