Abstract
Upper GI submucosal tumors (SMTs) <3 cm are generally considered benign tumors.1 However, some such tumors, especially mesenchymal neoplasms (including GI stromal tumors originating from the muscularis propria [MP]), do have malignant potential.2 If tissue diagnosis is attempted, the most challenging aspect in the diagnosis of SMTs by needle biopsy is the sampling error when taking biopsy specimens of GI stromal tumors, which may show only focal areas of malignant change.2 Asymptomatic GI SMTs <3 cm could be followed-up with periodic endoscopy and/or EUS or resection.
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