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Abstract
The activity of the enzymes, amylase and acid and alkaline ribonuclease, was utilizedin this study as a reflection of submaxillary glandular activity. These enzymes were measured in the submaxillary saliva of 9 patients with cystic fibrosis and in that of 9 normal children. Analysis revealed a three- to fivefold increase of amylase and two- to threefold increase of acid and alkaline ribonucleases in submaxillary saliva from patients with cystic fibrosis. The findings strongly support the concept of a generalized increase in the secretion of all organic constituents by the seromucoid glands of patients with cystic fibrosis.
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