Sublingual versus oral misoprostol for uterine evacuation following early pregnancy failure

Abstract

Objective To compare the efficacy of misoprostol administered sublingually or orally for uterine evacuation after early pregnancy failure. Method Forty-eight hours after receiving 200 mg of mifepristone orally, 100 women were randomized to receive misoprostol sublingually or orally. Results The evacuation rates were 92% in the sublingual and 84% in the oral administration group; the mean ± SD induction-to-evacuation intervals were 5.6 ± 4.54 hours and 9.44 ± 5.61 hours, this difference being significant; and the adverse effects were similar in the 2 groups. Conclusion The sublingual route was found to be as effective but faster than the oral route for uterine evacuation after early pregnancy failure.