Abstract
Study objectivesTo investigate the extent to which sleep quality associated with plasma Aβ levels in amnestic mild cognitive impairment (aMCI) elderly.MethodsA total of 172 cognitively normal (NC) elderly and 133 aMCI elderly were included in this study. For the evaluation of sleep quality, the Pittsburgh Sleep Quality Index (PSQI) was used. Levels of plasma Aβ were determined by the sandwich enzyme-linked immunosorbent assay technique. Multivariable linear regression analysis was applied to evaluate associations between sleep quality and plasma Aβ levels after adjusting potential confounders.ResultsCompared to NC subjects, participants with aMCI had a higher global PSQI score (8.72 ± 3.87 vs. 7.10 ± 3.07, p < 0.001). The global PSQI score was positively associated with plasma Aβ42 level in the aMCI group (β = 0.063, 95% CI 0.001–0.125, and p = 0.049) but not in the NC group (p > 0.05). Additionally, a higher global PSQI score was associated with a higher plasma Aβ42/Aβ40 ratio in both NC (β = 0.010, 95% CI 0.003–0.016, and p = 0.003) and aMCI groups (β = 0.012, 95% CI 0.005–0.018, and p < 0.001). The association between global PSQI score and plasma Aβ42/Aβ40 ratio was stronger in individuals with aMCI relative to the NC subjects (β = 0.076 vs. 0.030, p for interaction = 0.023).ConclusionPoor sleep quality was associated with plasma Aβ42 and Aβ42/Aβ40 ratio, with a stronger effect among individuals with aMCI. A better understanding of the role of sleep in plasma Aβ levels in aMCI patients could lead to effective sleep-based intervention against the risk of Alzheimer’s disease.
Highlights
Sleep disorders are commonly seen in older people and increase with age (Gadie et al, 2017)
The global Pittsburgh Sleep Quality Index (PSQI) score was positively associated with plasma Aβ42 level in the amnestic mild cognitive impairment (aMCI) group (β = 0.063, 95% confidence intervals (CIs) 0.001–0.125, and p = 0.049) but not in the NC group (p > 0.05)
We revealed that poor sleep quality was associated with increased plasma Aβ42 level in aMCI patients, as well as Aβ42/Aβ40 ratio in both NC and aMCI subjects
Summary
Sleep disorders are commonly seen in older people and increase with age (Gadie et al, 2017). Sleep Quality and Plasma Aβ in aMCI impairment and poor cognitive function (Ma et al, 2019). Sleep decreased Aβ production and increased clearance, while wakefulness leads to an increase of Aβ production in the brain (Slats et al, 2013; Xie et al, 2013). These underlying associations were confirmed by several studies. A prospective study with 70 cognitively healthy adults showed that poor sleep quality was associated with an increased Aβ burden in the brain (Spira et al, 2013)
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