Abstract

Patients suffering from Parkinson's disease (PD) complain more often about acute and chronic pain, which can be subdivided into musculoskeletal pain, radicular-neuropathic pain, dystonic pain, central pain and akathisia. Previous studies of experimentally induced pain in PD revealed heterogeneous results. One recent study detected an increased perception of heat-induced pain, which was reversible after dopaminergic treatment. Possibly a reduced dopaminergic descending inhibitory control (DNIC) system contributes to this finding. Therefore, we investigated the DNIC system by using a tonic heat stimulus and a phasic electrical stimulus. In addition to thermal and electrical pain thresholds, we assessed spinal nociception by using the nociceptive flexion reflex (NFR).

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