Abstract
We recently described the training of the passage from scheduled to demanded meals in infants and adults. Subjects reduced energy intake by subjectively abolishing conditioned meals and by allowing intake only after demand by the infant or after hunger perception by the adult (Initial Hunger Meal Pattern; IHMP). Conditioned meals were those scheduled and/or presented to the infant as well to the adult by sight, smell, mentioning, gesturing or simply at a fixed mealtime. During IHMP instead, meals were suspended until the first infant’s demand or until an adult’s self-noticing arousal of hunger. IHMP was checked by measuring blood glucose before three meals per day (MBG) and was associated with significant decreases in diary-reported energy-intake, MBG, glycated hemoglobin, body weight, insulin AUC in glucose tolerance tests and in days with diarrhea as compared to randomized control subjects who maintained conditioned meals. Although generalized, conditioned eating is a modern aberration that is associated with development of insulin resistance and overall inflammation. These associations are well demonstrated independently from the implicated mechanism. A state of Overall Subclinical Inflammation greatly increases cell and DNA replications and replication errors. After decades of DNA errors, oncogenic cells arise and cumulate. A prevention of malignancies is possible by interrupting the development of conditioned eating, insulin resistance and associated overall inflammation.
Highlights
In past studies, energy availability and Mean Blood Glucose (MBG) were maintained at different levels within the normal in time variability between 65 mg/dL and 110 mg/dL before meals and before any training on energy intake [1] [2]
IHMP was checked by measuring blood glucose before three meals per day (MBG) and was associated with significant decreases in diary-reported energy-intake, MBG, glycated hemoglobin, body weight, insulin AUC in glucose tolerance tests and in days with diarrhea as compared to randomized control subjects who maintained conditioned meals
After bearable meal suspension and recognition of ensuing hunger (Initial Hunger, IH) before all meals, the MBG decreased from 91.6 ± 7.7 mg/dL before training to 76.6 ± 3.7 mg/dL BG after training [1] [2]
Summary
Energy availability and Mean Blood Glucose (MBG) were maintained at different levels within the (sedentary) normal in time variability between 65 mg/dL and 110 mg/dL before meals and before any training on energy intake [1] [2]. After bearable meal suspension and recognition of ensuing hunger (Initial Hunger, IH) before all meals, the MBG decreased from 91.6 ± 7.7 mg/dL before training to 76.6 ± 3.7 mg/dL BG after training [1] [2]. A consistent minority (30% - 35%) of population maintains insulin resistance, high MBG and overall inflammation on one hand and cancer development on the other [1]-[6]. Recognition of initial hunger and prediction of current BG are easy in young people before 60 After this learning, people decrease energy intake by a mean 30% (of recruitment value). Brandtzaeg and Abrams calculated that more than half immune cells in the body were developing in the intestinal mucosa.
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