Abstract
Discriminating between those with and without subjective cognitive decline (SCD) in cross-sectional investigations using neuropsychological tests is challenging. The available magnetoencephalographic (MEG) studies have demonstrated altered alpha-band spectral power and functional connectivity in those with SCD. However, whether the functional connectivity in other frequencies and brain networks, particularly the default mode network (DMN), exhibits abnormalities in SCD remains poorly understood. We recruited 26 healthy controls (HC) without SCD and 27 individuals with SCD to perform resting-state MEG recordings. The power of each frequency band and functional connectivity within the DMN were compared between these two groups. Posterior cingulate cortex (PCC)-based connectivity was also used to test its diagnostic accuracy as a predictor of SCD. There were no significant between-group differences of spectral power in the regional nodes. However, compared with HC, those with SCD demonstrated increased delta-band and gamma-band functional connectivity within the DMN. Moreover, node strength in the PCC exhibited a good discrimination ability at both delta and gamma frequencies. Our data suggest that the node strength of delta and gamma frequencies in the PCC may be a good neurophysiological marker in the discrimination of individuals with SCD from those without SCD.
Highlights
Mild cognitive impairment (MCI) has been accepted as a symptomatic pre-dementia stage, over the past decade there has been an increasing interest in the pre-clinical asymptomatic stage of dementia, i.e., subjective cognitive decline (SCD)
According to the definition provided by the Subjective Cognitive Decline Initiative Working Group, SCD refers to a self-perceived worsening in cognitive capacity but a normal age- and education-adjusted performance on standardized cognitive assessments, which are used to diagnose mild cognitive impairment (MCI) and dementia [1]
The Receiver operating characteristic (ROC) curve data showed that the node strength of the delta and gamma frequencies in Posterior cingulate cortex (PCC) was a good www.aging-us.com neurophysiological marker for the discrimination of SCD from healthy controls (HC)
Summary
Mild cognitive impairment (MCI) has been accepted as a symptomatic pre-dementia stage, over the past decade there has been an increasing interest in the pre-clinical asymptomatic stage of dementia, i.e., subjective cognitive decline (SCD). It has been documented that SCD is potentially a pre-MCI stage Support for this contention is www.aging-us.com derived from longitudinal cohort studies showing strong associations between SCD and prospective objective cognitive performance, as well as the incidence of dementia [2,3,4,5]. Despite these promising findings, it remains difficult to investigate the functional correlates of SCD through cross-sectional studies. The cross-sectional identification of neural signatures of SCD has a great clinical impact on the early detection and prognostic prediction of the dementia spectrum
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