Abstract
The direct effects of adenosine on cardiac oxygen balance, hemodynamics and regional myocardial perfusion were studied in isolated canine hearts. Intracoronary infusion of adenosine produced a dose-dependent shift in the transmural distribution of coronary blood flow away from left ventricular subendocardium and a reduction in myocardial oxygen consymption (MVO 2). The data suggest that adenosine may partially decrease MVO 2 by a redistribution of flow from a high to low oxygen-extracting region of the myocardium.
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Schedule a callMore From: European Journal of Pharmacology: Molecular Pharmacology
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