Subcutaneous versus intramuscular administration of human chorionic gonadotropin during an in vitro fertilization cycle

Abstract

Objective To confirm that hCG levels in follicular fluid and serum would be comparable between IM and SC administration of purified hCG. Design In a prospective study, serum and follicular fluid levels of hCG after an IM or SC injection of 10,000 IU of hCG were evaluated 36 hours after injection, that is, at the time of oocyte retrieval. Setting This study was carried out in a university-affiliated IVF program. Patient(s) Forty women undergoing oocyte retrieval were entered into the study at the time of egg retrieval, that is, 36 hours after hCG administration. Intervention(s) SC or IM injection of hCG. Main outcome measure(s) Serum and follicular fluid concentrations of hCG were evaluated 36 hours after injection at the time of oocyte retrieval. Result(s) There was a significantly higher serum hCG level in the SC group (348.6 ± 98 IU/L) vs. the IM group (259.0 ± 115 IU/L) and a significantly higher follicular fluid hCG level in the SC vs. the IM group (233.5 ± 85 vs. 143.4 ± 134 IU/L). Conclusion(s) After purified hCG administration via the SC route, both serum and follicular fluid levels are greater compared with the IM route.