Abstract
Subcutaneous panniculitis-like T-cell lymphoma is a distinct variant of cutaneous T-cell lymphoma, characterized by primary involvement of the subcutaneous fat in a manner mimicking panniculitis. It accounts for less than one percent of all non Hodgkin lymphoma. We describe two such patients who presented with cutaneous nodules. A 28 year old male presented with a one and a half month history of multiple subcutaneous nodules over the thighs, abdominal wall and chest. A clinical diagnosis of panniculitis was made. An excision biopsy of one the nodules was performed and the histopathology revealed subcutaneous panniculitis-like T-cell lymphoma. The other patient was a 44 year old male who underwent excision of a subcutaneous mass in the right thigh and on histopathological examination a diagnosis of subcutaneous panniculitis-like T-cell lymphoma was made. The patients received one cycle of CHOP (cyclophoshamide, vincristine, doxorubicin and prednisolone) regimen, followed by systemic steroids and were advised follow up.
Highlights
Subcutaneous panniculitis-like T-cell lymphoma (SPTCL)originally described by Gonzalez et al is a primary cutaneous lymphoma (PCL) characterized by an aggressive clinical course and hypodermal involvement [1]
The lymphoma infiltrate in SPTCL involves the lobules of the subcutaneous fat, resulting in a characteristic lobular panniculitis like pattern
Distinguishing SPTCL from other types of cutaneous lymphomas is principally based on the subcutaneous localization of these lesions unlike the predominantly dermal involvement seen in mycosis fungoides, anaplastic large cell lymphoma, Natural Killer cell/ T-cell lymphoma [2,3,4,5,7,8]
Summary
Subcutaneous panniculitis-like T-cell lymphoma (SPTCL)originally described by Gonzalez et al is a primary cutaneous lymphoma (PCL) characterized by an aggressive clinical course and hypodermal involvement [1]. Subcutaneous Panniculitis- like T-Cell Lymphoma: Report of two cases. On histopathological examination of the lesion on the thighs of both the patients showed a diffuse cellular infiltrate involving the septae and lobules of subcutaneous fat (Fig. 2) in a lobular panniculitis like pattern, sparing the overlying dermis and epidermis.
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