Abstract
We cloned 537 basepairs (bp) of rat partial peroxisome proliferator-activated receptor γ2 (PPARγ2) cDNA and examined the effect of fasting or obesity on the expression of two isoforms of rat PPARγ, γ1 and γ2, in either subcutaneous or mesenteric adipose tissue specimens using an RNase A protection assay. In Wistar rats, expression of both isoforms was dramatically reduced after 48 hours of fasting in the two fat tissue specimens. In comparing genetically obese ( fa fa ) Zucker rats and lean control rats, no significant difference was observed in expression of the two isoforms in either type of adipose tissue. From these findings, we conclude that the adipose tissue level of rat PPARγ depends on nutritional deprivation but is not closely associated with either obesity or insulin resistance in obese Zucker rats.
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