Subcutaneous and Intravenous Administration of Human Umbilical Cord Mesenchymal Stem Cells in Patient With Multiple Foot Ulcers Complicated by Scleroderma- A Case Report with One Year Follow Up

Abstract

We treated a patient with progressive, refractory scleroderma with multiple ulcers on her feet with a combination of intravenous and a subcutaneous injection at the periphery of the ulcers using Umbilical Cord-Derived Mesenchymal Stem Cells (UCMSCs). The patient improved subjectively and objectively and we have followed up with the patient for 1 year. The combination was well tolerated and effective, suggesting a large-scale study may be warranted for progressive, refractory scleroderma ulcer treatment.